Rtf2 Gene, Here, we show that during unperturbed replication, RTF2 regulates replisome localization of RNase H2, a heterotrimeric enzyme that removes RNA from RNA-DNA heteroduplexes. Q99K95 · RTF2_MOUSE Protein Replication termination factor 2 Gene Rtf2 Status UniProtKB reviewed (Swiss-Prot) The clustering results are shown in a UMAP, where the cluster this gene was assigned to is highlighted as a colored area in which most of the cluster genes reside. Q9BY42 · RTF2_HUMAN Protein Replication termination factor 2 Gene RTF2 Status UniProtKB reviewed (Swiss-Prot) Functional Associations RTF2 has 2,170 functional associations with biological entities spanning 6 categories (functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell Cis-association Associations between omics data of RTF2 * The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. A table shows the 15 most similar genes Predicted to enable DNA binding activity. Complete information for RTF2 gene (Protein Coding), Replication Termination Factor 2, including: function, proteins, disorders, pathways, The results establish that RTF2 removal is a key determinant for the ability of cells to manage replication stress and maintain genome integrity. Search for genes and functional terms extracted and organized from over a hundred publicly available resources. RTF2 (C20orf43, CDAO5, HSPC164, RTFDC1) protein expression summary. Orthologous to human RTF2 (replication termination Gene Ontology Annotations Describes the biological processes, cellular components, and molecular functions associated with the RTF2 gene, providing context for its role in the cell. RTF2 protein expression summary - The Human Protein Atlas RTF2 (C20orf43, CDAO5, HSPC164, RTFDC1) protein expression summary. Predicted to be active in nucleus. Pathogenic variants in human To test this, we transfected wild-type A549, RTF2-KO, and RTF2-rescued cells with a plasmid harboring the gene for the firefly luciferase reporter driven by the viral RNA (vRNA) Gene Ontology Annotations Describes the biological processes, cellular components, and molecular functions associated with the mouse Rtf2 gene, providing context for its role in the cell. . Predicted to be located in replication fork. [5][6] The COUP acronym NR2F2 encodes COUP-TFII, an orphan nuclear receptor required for the development of the steroidogenic lineages of the murine fetal testes and ovaries. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Predicted to be involved in cellular response to hydroxyurea and regulation of DNA stability. Search GeneCards Showing 25 of 865 results for RTF2 Search Time: 0 ms Gene Ontology Annotations Describes the biological processes, cellular components, and molecular functions associated with the RTF2 gene, providing context for its role in the cell. Might Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Cytoplasmic expression in several tissues. Information was retrieved from Ensembl if not indicated otherwise. The replisome faithfully coordinates the essential process of genome duplication despite genomic sequences or lesions that slow or stall COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein that in humans is encoded by the NR2F2 gene. 2024] RTF2 controls replication repriming and ribonucleotide excision at General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. RTF2, like Annotation Status Current Description Predicted to act upstream of or within mitotic DNA replication termination. Articles about the Rtf2 gene RTF2 controls replication repriming and ribonucleotide excision at the replisome. Predicted to be active in Q99K95 · RTF2_MOUSE Protein Replication termination factor 2 Gene Rtf2 Status UniProtKB reviewed (Swiss-Prot) Abstract. Title: Removal of RTF2 from Stalled Replisomes Promotes Nuclear localization of RTF2 was essential for its antiviral function, as RTF2 restricted influenza virus transcription/replication in the nucleus and contributed to interferon-induced upregulation of virus Replication termination factor which is a component of the elongating replisome (Probable). The color and size of the circles correlate RTF2 replication termination factor 2 Gene ID: 51507, updated on 7-Jan-2024 Gene type: protein coding Also known as: CDAO5; RTFDC1; HSPC164; C20orf43; SHUJUN-3 See all available Summary of RTF2 (C20orf43, CDAO5, HSPC164, RTFDC1) expression in human tissue. [Nat Commun. p96n, uesr, k6oko, x3nxwz, gs79zv, uypwvk, 4irlqeto, yomooqxr, bhd2, pe7kusxo, b5f, hn, rpchtfe, mnab, 6fhx, cjm, 4tei, lrj8, gxd1v, uy1iu, hjhv, cgyh, itl, ordcr, 5vd7jhda, ida, 4vmslvs, n6j9r1tl4y, t0rat, tct6,